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Expression of Intestinal Alkaline Phosphatase in Human Organs by Ulla Domar; Berith Nilsson; Vladimir Baranov; Ulf Gerdes; Torgny Stigbrand is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Expression of Intestinal Alkaline Phosphatase in Human Organs about?

Human intestinal alkaline phosphatase was immunohistochemically identified and localized in the pancreas, liver and kidney by use of a monoclonal antibody specific for intestinal alkaline phosphatase isozyme and by amplified biotin-streptavidin staining. In all the examined organs, the intestinal isozyme was found to be localized in the epithelial cells of ducts: bile ducts in the liver, distal convoluted tubules and collecting tubules in the kidney and ducts in the secretory epithelium in the pancreas. In the liver the antibody also stained some sinus-lining cells. In all the examined organs the endothelial cells of the capillaries and some vessels were stained. By use of immunoelectron microscopy, intestinal alkaline phosphatase was, as expected, found to be localized to the microvillar region of the small intestine. The isozyme was abundantly expressed in the apical area of the microvilli and in membrane remnants in the fuzzy coat. Capillaries and vessels in the submucosa were also stained, as well as small vesicles in the endothelial cells. The present investigation demonstrates the expression and localization of the intestinal alkaline phosphatase in several organs, though pre

Who reads Expression of Intestinal Alkaline Phosphatase in Human Organs?

Author

Ulla Domar; Berith Nilsson; Vladimir Baranov; Ulf Gerdes; Torgny Stigbrand

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 1432-119X)

Published

1992

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)