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Current Therapeutic Interventions Combating Biofilm-related Infections in Orthopaedics by Jie Li; Wing-Hoi Cheung; Simon K. Chow; Margaret Ip; Sharon Y. S. Leung; Ronald M. Y. Wong is a Medicine article available to read on EtoBox.

What is Current Therapeutic Interventions Combating Biofilm-related Infections in Orthopaedics about?

## Aims Biofilm-related infection is a major complication that occurs in orthopaedic surgery. Various treatments are available but efficacy to eradicate infections varies significantly. A systematic review was performed to evaluate therapeutic interventions combating biofilm-related infections on in vivo animal models. ## Methods Literature research was performed on PubMed and Embase databases. Keywords used for search criteria were “bone AND biofilm”. Information on the species of the animal model, bacterial strain, evaluation of biofilm and bone infection, complications, key findings on observations, prevention, and treatment of biofilm were extracted. ## Results A total of 43 studies were included. Animal models used included fracture-related infections (ten studies), periprosthetic joint infections (five studies), spinal infections (three studies), other implant-associated infections, and osteomyelitis. The most common bacteria were Staphylococcus species. Biofilm was most often observed with scanning electron microscopy. The natural history of biofilm revealed that the process of bacteria attachment, proliferation, maturation, and dispersal would take 14 days. For systemic mon

Who reads Current Therapeutic Interventions Combating Biofilm-related Infections in Orthopaedics?

Author

Jie Li; Wing-Hoi Cheung; Simon K. Chow; Margaret Ip; Sharon Y. S. Leung; Ronald M. Y. Wong

Publisher

British Editorial Society of Bone & Joint Surgery

Published

2022

Language

EN

Field

Medicine (Health Sciences)