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Comprehensive characterization of HER2-low breast cancers: implications in prognosis and treatment by Yuyang Li; Julia Y. Tsang; Fiona Tam; Thomson Loong; Gary M. Tse is a Medicine article available to read on EtoBox.

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## Summary ## Background HER2-low cancers are heterogeneous with different degrees of HER2 expression and hormone receptor (HR) status. Currently, its analysis is mostly focused on the standard clinic-pathologic features or common biomarkers expression, without considering the heterogeneity within the category. A further characterization and understanding of this cancer subgroup will facilitate its management. ## Methods A large cohort of HER2-negative cancers (N = 1464) was included. The HER2-low (N = 412) and HER2-zero cancers (N = 1052) were compared and correlated with a comprehensive panel of clinico-pathologic features and biomarker expression according to different HER2 expressions and HR statuses. The prognostic values of these features in HER2-low cancers were also evaluated. ## Findings The characteristics of HER2-low breast cancers, as compared to HER2-zero, varied with the HR status. HER2-low luminal cancers were associated with younger age, larger tumor, high pAKT and high HLA expression. Among TNBCs, opposite trends in age and tumor size were found. Additionally, HER2-low TNBC showed less necrosis, higher pN, lower c-kit and CK14 than HER2-zero cancers. Nonetheless, r

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Author

Yuyang Li; Julia Y. Tsang; Fiona Tam; Thomson Loong; Gary M. Tse

Publisher

Elsevier

Published

2023

Language

EN

Field

Medicine (Life Sciences)