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Nephrotic syndrome is characterized by generalized edema, hyperlipidemia, and hypoalbuminemia. It can be caused by diseases such as diabetes, amyloidosis, or systemic lupus erythematosus (SLE) that damage the glomeruli. This leads to a decrease in colloid osmotic pressure and fluid accumulation in tissues. The glomeruli may undergo sclerosis or develop minimal changes, glomerulosclerosis, or membranous glomerulonephritis.

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