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Comparison of quality of life, work productivity and medical resource utilization of peginterferon alpha 2a vs the combination of interferon alpha 2b plus ribavirin as initial treatment in patients with chronic hepatitis C by R. Perrillo; K. D. Rothstein; R. Rubin; I. Alam; J. Imperial; G. Harb; S. Hu; W. Klaskala is a Medicine article available to read on EtoBox.

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**Summary.** The on‐treatment impact of interferon‐based therapies on quality of life (QOL), work productivity, and medical resource utilization has not been systematically studied. We evaluated the effects of treatment with peginterferon alpha (pegIFN__α__) 2a monotherapy and the combination of interferon alpha (IFN__α__) 2b plus ribavirin (RBV) on health‐related QOL, work productivity and resource utilization. A total of 412 patients with hepatitis C infection were randomized to open‐label treatment with either pegIFN__α__ 2a (__n__ = 206) or IFN__α__ 2b/RBV (__n__ = 206). PegIFN__α__ 2a was administered subcutaneously at a dose of 180 __μ__g once weekly for 48 weeks; and IFN__α__ 2b/RBV at doses of 3 MU thrice weekly subcutaneously and 1000–1200 mg/day orally. Outcome measures included the SF‐36 Health Survey Questionnaire and additional generic and specific scales. During treatment, for all SF‐36 summary and Hepatitis Quality of Life Questionnaire (HQLQ)‐specific scales, the pegIFN__α__ 2a group experienced less impairment than did the IFN__α__ 2b/RBV patients. The between‐treatment differences were significant for many of the scores particularly in the first 24 weeks of treatm

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Author

R. Perrillo; K. D. Rothstein; R. Rubin; I. Alam; J. Imperial; G. Harb; S. Hu; W. Klaskala

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1352-0504)

Published

2004

Language

EN

Field

Medicine (Health Sciences)