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Anticancer activity of natural cytokinins: A structure–activity relationship study by Jiří Voller; Marek Zatloukal; René Lenobel; Karel Doležal; Tibor Béreš; Vladimír Kryštof; Lukáš Spíchal; Percy Niemann; Petr Džubák; Marián Hajdúch; Miroslav Strnad is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Anticancer activity of natural cytokinins: A structure–activity relationship study about?
Cytokinin ribosides (N 6 -substituted adenosine derivatives) have been shown to have anticancer activity both in vitro and in vivo. This study presents the first systematic analysis of the relationship between the chemical structure of cytokinins and their cytotoxic effects against a panel of human cancer cell lines with diverse histopathological origins. The results confirm the cytotoxic activity of N 6 -isopentenyladenosine, kinetin riboside, and N 6 -benzyladenosine and show that the spectrum of cell lines that are sensitive to these compounds and their tissues of origin are wider than previously reported. The first evidence that the hydroxylated aromatic cytokinins (ortho-, meta-, para-topolin riboside) and the isoprenoid cytokinin cis-zeatin riboside have cytotoxic activities is presented. Most cell lines in the panel showed greatest sensitivity to ortho-topolin riboside (IC 50 = 0.5-11.6 lM). Cytokinin nucleotides, some synthesized for the first time in this study, were usually active in a similar concentration range to the corresponding ribosides. However, cytokinin free bases, 2-methylthio derivatives and both O-and N-glucosides showed little or no toxicity. Overall the stu
Who reads Anticancer activity of natural cytokinins: A structure–activity relationship study?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jiří Voller; Marek Zatloukal; René Lenobel; Karel Doležal; Tibor Béreš; Vladimír Kryštof; Lukáš Spíchal; Percy Niemann; Petr Džubák; Marián Hajdúch; Miroslav Strnad
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0031-9422)
- Published
- 2010
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)