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Sustained miRNA delivery from an injectable hydrogel promotes cardiomyocyte proliferation and functional regeneration after ischaemic injury by Leo L. Wang; Ying Liu; Jennifer J. Chung; Tao Wang; Ann C. Gaffey; Minmin Lu; Christina A. Cavanaugh; Su Zhou; Rahul Kanade; Pavan Atluri; Edward E. Morrisey; Jason A. Burdick is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Sustained miRNA delivery from an injectable hydrogel promotes cardiomyocyte proliferation and functional regeneration after ischaemic injury about?
H eart disease is the leading cause of mortality across the world-in the United States and Europe, heart disease contributes to 600,000 and 4,000,000 deaths each year, respectively 1,2 . Myocardial infarctions (MIs), or heart attacks, are individually linked to at least 50% of deaths 2 . During MI, blood supply to cardiac tissue is compromised, initiating a tissue remodelling response. Central to this process is the permanent loss of contractile cardiomyocytes, the native muscle cells in the heart, and the replacement of healthy tissue with non-contractile, fibrotic tissue. Improved management of acute MI through medical and surgical intervention has allowed up to 95% of patients to survive hospitalization 2 ; however, many of these patients will develop chronic heart failure, resulting in a 50% mortality rate at five years post-MI 2 .Since a hallmark of MI is cardiomyocyte cell death, increasing the number of cardiomyocytes within the damaged myocardium may improve cardiac function. The major challenge to this approach is the limited capacity for renewal of cardiomyocytes in the adult heart . Cardiomyocytes are often thought of as being terminally differentiated, exiting the cell
Who reads Sustained miRNA delivery from an injectable hydrogel promotes cardiomyocyte proliferation and functional regeneration after ischaemic injury?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Leo L. Wang; Ying Liu; Jennifer J. Chung; Tao Wang; Ann C. Gaffey; Minmin Lu; Christina A. Cavanaugh; Su Zhou; Rahul Kanade; Pavan Atluri; Edward E. Morrisey; Jason A. Burdick
- Publisher
- Springer Science and Business Media LLC
- Published
- 2017
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)