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Can I read α lipoic acid inhibits human T‐cell migration: Implications for multiple sclerosis on EtoBox?
α lipoic acid inhibits human T‐cell migration: Implications for multiple sclerosis by Gail H. Marracci; Gabriel P. McKeon; Whitney E. Marquardt; Rolf W. Winter; Michael K. Riscoe; Dennis N. Bourdette is a Neuroscience article available to read on EtoBox.
What is α lipoic acid inhibits human T‐cell migration: Implications for multiple sclerosis about?
## Abstract We have demonstrated previously the ability of the antioxidant α lipoic acid (ALA) to suppress and treat a model of multiple sclerosis (MS), relapsing experimental autoimmune encephalomyelitis (EAE). We describe the effects of ALA and its reduced form, dihydrolipoic acid (DHLA), on the transmigration of human Jurkat T cells across a fibronectin barrier in a transwell system. ALA and DHLA inhibited migration of Jurkat cells in a dose‐dependent fashion by 16–75%. ALA and DHLA reduced matrix metalloproteinase‐9 (MMP‐9) activity by 18–90% in Jurkat cell supernatants. GM6001, a synthetic inhibitor of MMP, reduced Jurkat cell migration, but not as effectively as ALA and DHLA did. Both ALA and DHLA downmodulated the surface expression of the α4β1 integrin (very late activation‐4 antigen; VLA‐4), which binds fibronectin and its endothelial cell ligand vascular cell adhesion molecule‐1 (VCAM‐1). Moreover, ALA, but not DHLA, reduced MMP‐9‐specific mRNA and extracellular MMP‐9 from Jurkat cells and their culture supernatants as detected by relative reverse transcriptase‐polymerase chain reaction (RT‐PCR) and enzyme‐linked immunosorbent assay (ELISA), respectively. ALA and DHLA inh
Who reads α lipoic acid inhibits human T‐cell migration: Implications for multiple sclerosis?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Gail H. Marracci; Gabriel P. McKeon; Whitney E. Marquardt; Rolf W. Winter; Michael K. Riscoe; Dennis N. Bourdette
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 2004
- Language
- EN
- Field
- Neuroscience (Life Sciences)