Can I read A longitudinal study on the natural history of serum hepatitis B surface antigen changes in chronic hepatitis B on EtoBox?

A longitudinal study on the natural history of serum hepatitis B surface antigen changes in chronic hepatitis B by Henry Lik-Yuen Chan; Vincent Wai-Sun Wong; Grace Lai-Hung Wong; Chi-Hang Tse; Hoi-Yun Chan; Joseph Jao-Yao Sung is a Medicine article available to read on EtoBox.

What is A longitudinal study on the natural history of serum hepatitis B surface antigen changes in chronic hepatitis B about?

Serum hepatitis B surface antigen (HBsAg) quantification has been suggested to reflect the concentration of covalently closed circular DNA in the liver. We aimed to investigate the HBsAg levels at different stages of chronic hepatitis B and the changes in HBsAg level during the natural progression of disease. One hundred seventeen untreated patients with chronic hepatitis B were studied with longitudinal follow-up for 99 ± 16 months. HBsAg quantification was performed at the first visit, the last visit, and three visits at each quartile during the follow-up. At the first visit, HBsAg level was higher among patients who were hepatitis B e antigen (HBeAg)-positive (N = 49) than those who were HBeAg-negative (N = 68) (4.01 ± 0.91 log IU/mL versus 2.73 ± 1.25 log IU/mL, P 1 log IU/mL at the last visit; most of them showed reduced hepatitis B virus DNA, and eight had HBsAg loss. ## Conclusion: Hbsag remained stable in hbeag-positive patients and tended to reduce slowly in hbeag-negative patients. reduction of hbsag for >1 log iu/ml could reflect improved immune control.

Who reads A longitudinal study on the natural history of serum hepatitis B surface antigen changes in chronic hepatitis B?

Author

Henry Lik-Yuen Chan; Vincent Wai-Sun Wong; Grace Lai-Hung Wong; Chi-Hang Tse; Hoi-Yun Chan; Joseph Jao-Yao Sung

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2010

Language

EN

Field

Medicine (Health Sciences)