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Can I read Retrieval Accuracy, Statistical Significance and Compositional Similarity in Protein Sequence Database Searches on EtoBox?
Retrieval Accuracy, Statistical Significance and Compositional Similarity in Protein Sequence Database Searches by Yi-Kuo Yu; E. Michael Gertz; Richa Agarwala; Alejandro A. Schäffer; Stephen F. Altschul is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Retrieval Accuracy, Statistical Significance and Compositional Similarity in Protein Sequence Database Searches about?
Protein sequence database search programs may be evaluated both for their retrieval accuracy—the ability to separate meaningful from chance similarities—and for the accuracy of their statistical assessments of reported alignments. However, methods for improving statistical accuracy can degrade retrieval accuracy by discarding compositional evidence of sequence relatedness. This evidence may be preserved by combining essentially independent measures of alignment and compositional similarity into a unified measure of sequence similarity. A version of the BLAST protein database search program, modified to employ this new measure, outperforms the baseline program in both retrieval and statistical accuracy on ASTRAL, a SCOP-based test set.
Who reads Retrieval Accuracy, Statistical Significance and Compositional Similarity in Protein Sequence Database Searches?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yi-Kuo Yu; E. Michael Gertz; Richa Agarwala; Alejandro A. Schäffer; Stephen F. Altschul
- Publisher
- Oxford University Press
- Published
- 2006
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)