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Replication study and meta-analysis of selected genetic variants and polycystic ovary syndrome susceptibility in Asian population by Pengcheng Wan; Linghan Meng; Chao Huang; Baosheng Dai; Yuchen Jin; Longlong Chai; Xiuli Gu; Bifeng Chen; Song Quan is a Medicine article available to read on EtoBox.

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## Purpose: Polycystic ovary syndrome (pcos) is a highly complex disorder influenced by genetic and environmental factors. previous association studies have identified multiple pcos-susceptible loci, but there is no consistent conclusion, which calls for further investigations. ## Methods: In the present case-control study, fshr gene variants (rs2268361, rs6165, and rs6166), lhcgr gene variant (rs13405728), thada gene variant (rs13429458), dennd1a gene variants (rs10818854 and rs2479106), and insr gene variants (rs2059807 and rs1799817) were genotyped with sanger sequencing in a total of 400 pcos women and 480 healthy women. ## Results: After bonferroni correction, our results showed that rs13405728, rs13429458, rs2479106, rs10818854, and rs2059807 were significantly associated with pcos risk in chinese women. to improve the statistical strength, a further meta-analysis in asian population was conducted. although rs6166 and rs1799817 were not associated with pcos risk in the present study, they were identified to be strongly associated with pcos risk in the pooled koreans and chinese respectively. no significant association with pcos risk was consistently found for rs2268361 or rs6

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Author

Pengcheng Wan; Linghan Meng; Chao Huang; Baosheng Dai; Yuchen Jin; Longlong Chai; Xiuli Gu; Bifeng Chen; Song Quan

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)