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Preoperative Nested Reverse Transcription‐polymerase Chain Reaction for Prostate Specific Membrane Antigen Predicts Biochemical Recurrence After Radical Prostatectomy by Okegawa; Nutahara; Higashihara is a Medicine article available to read on EtoBox.

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## Objective To assess the utility of the nested reverse transcription‐polymerase chain reaction (RT‐PCR) method for measuring prostate specific membrane antigen (PSM) and prostate specific antigen (PSA) in predicting serum PSA recurrence after radical prostatectomy. ## Patients and methods Nested RT‐PCRs for PSM and PSA were used in 40 patients who subsequently underwent radical prostatectomy. The accuracy of the RT‐PCR assays in predicting PSA failure was compared with those for the preoperative serum PSA level, Gleason score and final pathological staging. The patients were monitored using a PSA assay (Tandem‐R, Hybritech, San Diego, CA) at 3 weeks after radical prostatectomy and every 2 months thereafter. Biochemical recurrence was defined as a serum PSA level of ≥0.4 ng/mL. ## Results Statistical analysis indicated that the nested RT‐PCR assay for PSM was the most accurate preoperative predictor of potential surgical failure (PCR‐PSM, __P__<0.001; PCR‐PSA, __P__=0.018; serum PSA level, __P__=0.149; Gleason score __P__=0.388, by Fisher’s exact probability test). Biochemical recurrence was evaluated in relation to these methods during a mean (range) follow‐up of 16.7 (6–35) mont

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Author

Okegawa; Nutahara; Higashihara

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1464-4096)

Published

1999

Language

EN

Field

Medicine (Health Sciences)