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What is Virus Epitope Identification via TCRs about?

Researchers have developed a novel workflow that identifies virus epitopes and their corresponding T-cell receptors (TCRs) directly from memory T cells without the need for peptide synthesis. This method utilizes a tandem minigene system and yeast display technology to enhance epitope mapping, demonstrating its effectiveness in recognizing immune responses against SARS-CoV-2. The findings suggest potential applications for T-cell vaccine development and TCR-T cell therapies, particularly for immunocompromis

Author

mukherjeedebayan05

Language

EN