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Pyk2 by useretail is a document available to read on EtoBox.

The document discusses how Pyk2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility. It shows that Pyk2 facilitates deregulated RhoA activation, elevated focal adhesion formation, and enhanced cell proliferation by promoting p190RhoGEF expression. Knockdown experiments demonstrate that p190RhoGEF is important for focal adhesion formation and cell migration downstream of integrin binding to fibronectin.

Author

useretail

Language

EN