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Can I read Regulatory T cells and treatment of cancer on EtoBox?
Regulatory T cells and treatment of cancer by Tyler J Curiel is a Immunology and Microbiology article available to read on EtoBox.
What is Regulatory T cells and treatment of cancer about?
CD4+CD25+FOXP3+ regulatory T cells (Tregs) are elevated in cancers and can thwart protective antitumor immunity. Recent human cancer trials suggest that depleting Tregs can be clinically beneficial. Additional types of deleterious regulatory cells are also increased in cancer. Tregs also play unanticipated roles in cancer therapy in that some drugs unexpectedly increase (e.g. cancer vaccines or IL-2 treatment) or decrease (e.g. antineoangiogenesis agents or receptor tyrosine kinase inhibitors) their numbers or function. Managing deleterious effects of regulatory cells represents a novel and potentially effective way to give immunotherapy for cancer. New insights into molecular mechanisms governing trafficking, differentiation, and function of these cells suggest novel approaches to manipulating them as treatment strategies.
Who reads Regulatory T cells and treatment of cancer?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Tyler J Curiel
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0952-7915)
- Published
- 2008
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)