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Steroidogenic Acute Regulatory Protein in the Rat Brain: Cellular Distribution, Developmental Regulation and Overexpression After Injury by Amanda Sierra; Esteban Lavaque; Margarita Perez-Martin; Iñigo Azcoitia; Dale Buchanan Hales; Luis M. Garcia-Segura is a Neuroscience article available to read on EtoBox.
What is Steroidogenic Acute Regulatory Protein in the Rat Brain: Cellular Distribution, Developmental Regulation and Overexpression After Injury about?
## Abstract The central nervous system synthesizes steroids which regulate the development and function of neurons and glia and have neuroprotective properties. The first step in this process involves the delivery of free cholesterol to the inner mitochondrial membrane where it can be converted into pregnenolone. This delivery is mediated by steroidogenic acute regulatory protein (StAR). Here, we present a detailed analysis of the distribution of StAR expression in neurons and glia, in the developing, adult and aged male rat brain. Immunohistochemical analysis revealed that StAR is widely distributed throughout the brain, although in each brain area it is restricted to very specific neuronal and astroglial populations. In most regions expressing StAR, immunoreactivity appeared at P10 and the levels of expression then either increased or remained constant until adulthood. In 2‐year‐old rat brains, StAR immunoreactivity was increased compared to young adults. StAR was expressed in the subventricular zone of the adult brain, in proliferating cells which incorporate BrdU as well as in germinal layers in the developing brain. These findings indicate that StAR expression is developmental
Who reads Steroidogenic Acute Regulatory Protein in the Rat Brain: Cellular Distribution, Developmental Regulation and Overexpression After Injury?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Amanda Sierra; Esteban Lavaque; Margarita Perez-Martin; Iñigo Azcoitia; Dale Buchanan Hales; Luis M. Garcia-Segura
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)
- Published
- 2003
- Language
- EN
- Field
- Neuroscience (Life Sciences)