About this Medicine article
Validation of the proton range accuracy and optimization of CT calibration curves utilizing range probing by A Meijers; J Free; D Wagenaar; S Deffet; A C Knopf; J A Langendijk; S Both is a Medicine article available to read on EtoBox.
Proton therapy is affected by range uncertainty, which is partly caused by an ambiguous conversion from x-ray attenuation to proton stopping power. CT calibration curves, or Hounsfield look-up tables (HLUTs), are institution-specific and may be a source of systematic errors in treatment planning. A range probing method to verify, optimize and validate HLUTs for proton treatment is proposed. An initial HLUT was determined according to the stoichiometric approach. For HLUT validation, three types of animal tissue phantoms were prepared: a pig's head, 'thorax' and femur. CT scans of the phantoms were taken and a structure, simulating a water slab, was added on the scan distal to the phantoms to mimic the detector used for integral depth-dose measurements. The CT scans were imported into the TPS to calculate individual pencil beams directed through the phantoms. The phantoms were positioned at the therapy system isocenter using x-ray imaging. Shoot-through pencil beams were delivered, and depth-dose profiles were measured using a multi-layer ionization chamber. Measured depth-dose curves were compared to the calculated curves and the range error per spot was determined. Based on the wa
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- Author
- A Meijers; J Free; D Wagenaar; S Deffet; A C Knopf; J A Langendijk; S Both
- Publisher
- Institute of Physics; IOP Publishing; Institute of Physics Publishing (ISSN 0031-9155)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)