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First Results of a Phase II Trial Investigating Individualized Dose-escalation Based on Normal Tissue Constraints in Concurrent Chemo-radiation for Locally Advanced Non-small Cell Lung Cancer (NSCLC) (NCT00572325) by A. Van Baardwijk; R. Wanders; B. Reymen; J. Borger; A. Dingemans; G. Bootsma; C. Pitz; W. Geraedts; P. Lambin; D. De Ruysscher is a Medicine article available to read on EtoBox.

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biologically equivalent doses of 60-110 Gy in 2 Gy fractions. Sequential chemotherapy was given at the discretion of the medical oncologist and concurrent chemotherapy was not allowed. Clinical and radiographic assessments were performed at 3-month intervals. Results: With a median follow-up of 13.3 months (range, 1.1 to 67.3 months) no grade 3 or greater pneumonitis or esophageal toxicity developed in any of the treated patients. Eleven patients developed grade 2 pneumonitis. Acute grade 2 esophagitis developed in seven patients; two patients had late grade 2 esophageal toxicity. Estimated overall survival and local control at 2 yrs was 44% and 52%, respectively. For patients with large volume disease and resultant higher normalized lung doses, treatment at higher dose levels was predominantly limited by spinal cord and esophagus constraints. Conclusions: Dose escalation for NSCLC using a 25 fraction regimen can be safely achieved when guided by the mean lung relative normalized tissue dose. The maximum tolerated dose under the parameters of this dose escalation protocol has not been reached.

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Author

A. Van Baardwijk; R. Wanders; B. Reymen; J. Borger; A. Dingemans; G. Bootsma; C. Pitz; W. Geraedts; P. Lambin; D. De Ruysscher

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2010

Language

EN

Field

Medicine (Health Sciences)