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Dynamic Functional Connectivity Patterns Associated with Dementia Risk by Sophie Dautricourt; Julie Gonneaud; Brigitte Landeau; Vince D. Calhoun; Robin de Flores; Géraldine Poisnel; Salma Bougacha; Valentin Ourry; Edelweiss Touron; Elizabeth Kuhn; Harriet Demintz-King; Natalie L. Marchant; Denis Vivien; Vincent de la Sayette; Antoine Lutz; Gaël Chételat; Eider M. Arenaza-Urquijo; Eider M. Arenaza-Urquijo; Florence Allais; Claire André; Julien Asselineau; Alexandre Bejanin; Pierre Champetier; Gaël Chételat; Anne Chocat; Sophie Dautricourt; Robin de Flores; Marion Delarue; Stéphanie Egret; Francesca Felisatti; Eglantine Ferrand Devouge; Eric Frison; Julie Gonneaud; Marc Heidmann; Thien Huong Tran; Elizabeth Kuhn; Gwendoline le Du; Brigitte Landeau; Valérie Lefranc; Antoine Lutz; Florence Mezenge; Inès Moulinet; Valentin Ourry; Cassandre Palix; Léo Paly; Géraldine Poisnel; Anne Quillard; Géraldine Rauchs; Stéphane Rehel; Florence Requier; Edelweiss Touron; Denis Vivien; Caitlin Ware; Sebastian Baez Lugo; Olga Klimecki; Patrik Vuilleumier; Thorsten Barnhofer; Fabienne Collette; Eric Salmon; Vincent de la Sayette; Pascal Delamillieure; Martine Batchelor; Axel Beaugonin; Francis Gheysen; Harriet Demnitz-King; Natalie Marchant; Tim Whitfield; Corinne Schimmer; Miranka Wirth is a Medicine article available to read on EtoBox.

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## Background This study assesses the relationships between dynamic functional network connectivity (DFNC) and dementia risk. ## Methods DFNC of the default mode (DMN), salience (SN), and executive control networks was assessed in 127 cognitively unimpaired older adults. Stepwise regressions were performed with dementia risk and protective factors and biomarkers as predictors of DFNC. ## Results Associations were found between times spent in (i) a “weakly connected” state and lower self-reported engagement in early- and mid-life cognitive activity and higher LDL cholesterol; (ii) a “SN-negatively connected” state and higher blood pressure, higher depression score, and lower body mass index (BMI); (iii) a “strongly connected” state and higher self-reported engagement in early-life cognitive activity, Preclinical Alzheimer’s cognitive composite-5 score, and BMI; and (iv) a “DMN-negatively connected” state and higher self-reported engagement in early- and mid-life stimulating activities and lower LDL cholesterol and blood pressure. The lower number of state transitions was associated with lower brain perfusion. ## Conclusion DFNC states are differentially associated with dementia risk

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Author

Sophie Dautricourt; Julie Gonneaud; Brigitte Landeau; Vince D. Calhoun; Robin de Flores; Géraldine Poisnel; Salma Bougacha; Valentin Ourry; Edelweiss Touron; Elizabeth Kuhn; Harriet Demintz-King; Natalie L. Marchant; Denis Vivien; Vincent de la Sayette; Antoine Lutz; Gaël Chételat; Eider M. Arenaza-Urquijo; Eider M. Arenaza-Urquijo; Florence Allais; Claire André; Julien Asselineau; Alexandre Bejanin; Pierre Champetier; Gaël Chételat; Anne Chocat; Sophie Dautricourt; Robin de Flores; Marion Delarue; Stéphanie Egret; Francesca Felisatti; Eglantine Ferrand Devouge; Eric Frison; Julie Gonneaud; Marc Heidmann; Thien Huong Tran; Elizabeth Kuhn; Gwendoline le Du; Brigitte Landeau; Valérie Lefranc; Antoine Lutz; Florence Mezenge; Inès Moulinet; Valentin Ourry; Cassandre Palix; Léo Paly; Géraldine Poisnel; Anne Quillard; Géraldine Rauchs; Stéphane Rehel; Florence Requier; Edelweiss Touron; Denis Vivien; Caitlin Ware; Sebastian Baez Lugo; Olga Klimecki; Patrik Vuilleumier; Thorsten Barnhofer; Fabienne Collette; Eric Salmon; Vincent de la Sayette; Pascal Delamillieure; Martine Batchelor; Axel Beaugonin; Francis Gheysen; Harriet Demnitz-King; Natalie Marchant; Tim Whitfield; Corinne Schimmer; Miranka Wirth

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)