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Pharmacokinetics of the Anti-inflammatory Drug Ximoprofen in Healthy Subjects and in Disease States by I. W. Taylor; T. Taylor; I. James; G. Doyle; G. Dorf; A. Darragh; L. F. Chasseaud is a Medicine article available to read on EtoBox.

What is Pharmacokinetics of the Anti-inflammatory Drug Ximoprofen in Healthy Subjects and in Disease States about?

The pharmacokinetics of ximoprofen, a potent new non-steroidal anti-inflammatory agent, has been investigated in normal healthy subjects and in patients with hepatic or renal disease. After intravenous infusion of 22.8 mg to healthy subjects, plasma ximoprofen concentrations declined in a polyexponential manner with a terminal phase half-life of 1.9 h. The systemic clearance of ximoprofen was 115 ml.min-1 and the volumes of distribution were 18.01 Vz and 13.81 Vss. Ximoprofen was 80-90% bound to plasma proteins. The systemic availabilities (f) of orally and rectally administered doses of 30 mg of ximoprofen were 98% and 56% respectively and, in the case of the rectal dose, absorption appeared to be prolonged leading to "flip-flop" kinetics. After single oral doses of 30 mg of ximoprofen to patients with hepatic disease, half-life (2.2 h), peak plasma concentrations (1.55 micrograms.ml-1 cf 1.04 micrograms.ml-1 in healthy subjects) and areas under the curve (6.12 micrograms.h.ml-1 cf 3.54 micrograms.h.ml-1 in healthy subjects) were significantly different from those in healthy subjects. After single oral doses of 30 mg of ximoprofen to patients with renal disease, pharmacokinetic pa

Who reads Pharmacokinetics of the Anti-inflammatory Drug Ximoprofen in Healthy Subjects and in Disease States?

Author

I. W. Taylor; T. Taylor; I. James; G. Doyle; G. Dorf; A. Darragh; L. F. Chasseaud

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0031-6970)

Published

1990

Language

EN

Field

Medicine (Health Sciences)