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Reverse Re-modelling Chronic Heart Failure by Reinstating Heart Rate Variability by J. Shanks; Y. Abukar; N. A. Lever; M. Pachen; I. J. LeGrice; D. J. Crossman; A. Nogaret; J. F. R. Paton; R. Ramchandra is a Medicine article available to read on EtoBox.

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## Abstract Heart rate variability (HRV) is a crucial indicator of cardiovascular health. Low HRV is correlated with disease severity and mortality in heart failure. Heart rate increases and decreases with each breath in normal physiology termed respiratory sinus arrhythmia (RSA). RSA is highly evolutionarily conserved, most prominent in the young and athletic and is lost in cardiovascular disease. Despite this, current pacemakers either pace the heart in a metronomic fashion or sense activity in the sinus node. If RSA has been lost in cardiovascular disease current pacemakers cannot restore it. We hypothesized that restoration of RSA in heart failure would improve cardiac function. Restoration of RSA in heart failure was assessed in an ovine model of heart failure with reduced ejection fraction. Conscious 24 h recordings were made from three groups, RSA paced (n = 6), monotonically paced (n = 6) and heart failure time control (n = 5). Real-time blood pressure, cardiac output, heart rate and diaphragmatic EMG were recorded in all animals. Respiratory modulated pacing was generated by a proprietary device (Ceryx Medical) to pace the heart with real-time respiratory modulation. RSA p

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Author

J. Shanks; Y. Abukar; N. A. Lever; M. Pachen; I. J. LeGrice; D. J. Crossman; A. Nogaret; J. F. R. Paton; R. Ramchandra

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)