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Insight Into Cross-talk Between Intra-amoebal Pathogens by Gregory Gimenez; Claire Bertelli; Claire Moliner; Catherine Robert; Didier Raoult; Pierre-Edouard Fournier; Gilbert Greub is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Insight Into Cross-talk Between Intra-amoebal Pathogens about?

## Background Amoebae are phagocytic protists where genetic exchanges might take place between amoeba-resistant bacteria. These amoebal pathogens are able to escape the phagocytic behaviour of their host. They belong to different bacterial phyla and often show a larger genome size than human-infecting pathogens. This characteristic is proposed to be the result of frequent gene exchanges with other bacteria that share a sympatric lifestyle and contrasts with the genome reduction observed among strict human pathogens. ## Results We sequenced the genome of a new amoebal pathogen, __Legionella drancourtii__, and compared its gene content to that of a __Chlamydia-__related bacterium, __Parachlamydia acanthamoebae__. Phylogenetic reconstructions identified seven potential horizontal gene transfers (HGTs) between the two amoeba-resistant bacteria, including a complete operon of four genes that encodes an ABC-type transporter. These comparisons pinpointed potential cases of gene exchange between __P. acanthamoebae__ and __Legionella pneumophila__, as well as gene exchanges between other members of the __Legionellales__ and __Chlamydiales__ orders. Moreover, nine cases represent possible HG

Who reads Insight Into Cross-talk Between Intra-amoebal Pathogens?

Author

Gregory Gimenez; Claire Bertelli; Claire Moliner; Catherine Robert; Didier Raoult; Pierre-Edouard Fournier; Gilbert Greub

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2000-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2164)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)