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Cutaneous responses to substance P and calcitonin gene-related peptide in chronic urticaria: the effect of cetirizine and dimethindene: SP and CGRP in urticaria by R Borici-mazi; S Kouridakis; K Kontou-fili is a Medicine article available to read on EtoBox.

What is Cutaneous responses to substance P and calcitonin gene-related peptide in chronic urticaria: the effect of cetirizine and dimethindene: SP and CGRP in urticaria about?

Background: Neuropeptides appear to participate in the pathogenesis of chronic urticaria. The purpose of this study was to investigate the cutaneous responses to substance P (SP) and calcitonin gene-related peptide (CGRP) in delayed pressure urticaria patients (DPUpt) and chronic idiopathic urticaria patients (CIUpt) compared to healthy adults (HA), and also to evaluate the effect of H 1 -antagonists on these responses. Methods: Wheal (W) and ̄are (F) reactions to intradermally (ID) injected SP, CGRP, histamine (H), and diluent controls were evaluated in nine CIUpt, nine DPUpt, and nine HA at 3, 7, 15, 30, 60, and 120 min after injection. Maximal W and F, area under curve (AUC), and time of W and F disappearance were calculated at baseline and 4 h after a single dose of 20 mg cetirizine (Ce), 4 mg dimethindene (Di), or placebo (P), in a double-blind, placebo-controlled (DBPC), crossover, randomized study. Results: CIUpt exhibited enhanced and longer lasting W reactions to SP and CGRP (AUC: P,0.05) than HA; SP-and CGRP-induced F (at maximal concentration) were larger and longer lasting in CIUpt than in HA (P,0.003 and P=0.004, respectively). In the DPU group, SP-induced W and F res

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Author

R Borici-mazi; S Kouridakis; K Kontou-fili

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0105-4538)

Published

1999

Language

EN

Field

Medicine (Health Sciences)