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Quantification of Cerebral Arterial Blood Volume Using Arterial Spin Labeling with Intravoxel Incoherent Motion-sensitive Gradients by Tae Kim; Seong-Gi Kim is a Medicine article available to read on EtoBox.

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## Abstract Quantification of cerebral arterial blood volume (CBV~a~) is important for understanding vascular regulation. To enable measurement of CBV~a~ with diffusion‐weighted (DW) arterial spin labeling (ASL), a theoretical framework was developed using the effects of intravoxel incoherent motion (IVIM). The pseudo‐diffusion coefficient (__D__\*) in the IVIM model was evaluated at 9.4 T in DW‐ASL of rat brain under isoflurane anesthesia by variations of both post‐labeling delay (__w__) and magnetization transfer ratio (MTR). __D__\* and its volume fraction decreased at values of __w__ ≥ 0.3 s, and the normalized apparent diffusion coefficient (ADC) increased with MTR, suggesting that __D__\* is closely correlated with CBV~a~. Thus, the difference between ASL measurements with and without DW gradients is related to CBV~a~. The CBV~a~ values measured by this approach were compared with values obtained using the modulation of tissue and vessel (MOTIVE) technique with ASL, which varies MT levels without changing spin labeling efficiency. CBV~a~ values from both methods were highly correlated. The measured CBV~a~ values were linearly correlated with cerebral blood flow (CBF) for a Pa

Who reads Quantification of Cerebral Arterial Blood Volume Using Arterial Spin Labeling with Intravoxel Incoherent Motion-sensitive Gradients?

Author

Tae Kim; Seong-Gi Kim

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

2006

Language

EN

Field

Medicine (Health Sciences)