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Histomorphologic and immunophenotypic analysis of fibrofolliculomas and trichodiscomas in Birt–Hogg–Dube syndrome and sporadic disease by Gary L. Collins; Stephen Somach; Michael B. Morgan is a Medicine article available to read on EtoBox.

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**Background:** Fibrofolliculomas and trichodiscomas are benign dermal neoplasms that likely derive from the mantle of the hair follicle and can occur sporadically or in association with Birt–Hogg–Dube syndrome (BHDS). Little is known about the pathogenesis and immunophenotypic properties of these entities. **Methods:** We investigated the histomorphologic and immnophenotypic properties of 15 fibrofolliculomas and trichodiscomas in two patients with BHDS and eight with sporadic disease. **Results:** We found the following: (1) fibrofolliculomas and trichodiscomas occurring in the setting of BHDS show microscopically contiguous histomorphologic features as compared to those occurring sporadically; (2) the immunophenotypic characteristics of syndromic‐associated and sporadic types are identical and consist of (3) perifollicular vimentin (+), CD34 (+) and Factor XIII (–) spindle cells. **Conclusions:** Despite subtle histomorphologic differences, trichodiscomas and fibrofolliculomas are immunophenotypically similar, and are thus likely derived from a similar histogenic precursor. Given the previously reported CD34 (+) immunophenotype of the hair mantle, our findings would support an

Who reads Histomorphologic and immunophenotypic analysis of fibrofolliculomas and trichodiscomas in Birt–Hogg–Dube syndrome and sporadic disease?

Author

Gary L. Collins; Stephen Somach; Michael B. Morgan

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0303-6987)

Published

2002

Language

EN

Field

Medicine (Health Sciences)