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Enantiomeric separation of N-protected amino acids by non-aqueous capillary electrophoresis with dimeric forms of quinine and quinidine derivatives serving as chiral selectors by Véronique Piette; Wolfgang Lindner; Jacques Crommen is a Chemistry article available to read on EtoBox.

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A non-aqueous capillary electrophoretic method with quinine and tert.-butyl carbamoylated quinine as chiral selectors was developed previously for the enantioseparation of N-protected amino acids. This system was here applied as a screening tool for a fast evaluation of the chiral discrimination potential of six new dimeric forms of carbamoylated quinine and quinidine derivatives as chiral additives: 1,3-phenylene-bis(carbamoylated quinine), 1,6-hexamethylene-bis(carbamoylated quinine), 1,6-hexamethylene-bis(carbamoylated quinidine), trans-1,4-cyclohexylene-bis(carbamoylated quinine), trans-1,4-cyclohexylene-bis(carbamoylated-11-dodecylthio-dihydroquinine) and trans-1,4-cyclohexylene-bis(carbamoylated-11-dodecylsulfinyl-dihydroquinine). A series of 24 chiral acids, as various benzoyl, 3,5-dinitrobenzoyl (DNB) and 3,5-dinitrobenzyloxycarbonyl amino acid derivatives were investigated with regards to enantioselectivity employing these different dimeric chiral selectors. The composition of the background electrolyte was 12.5 mM ammonia, 100 mM octanoic acid, and 10 mM chiral selector in an ethanol-methanol (60:40, v/v) mixture and the enantioseparations were performed at 15 degrees C a

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Author

Véronique Piette; Wolfgang Lindner; Jacques Crommen

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)

Published

2002

Language

EN

Field

Chemistry (Physical Sciences)