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Traumatic memory reactivation with or without propranolol for PTSD and comorbid MD symptoms: a randomised clinical trial by Pascal Roullet; Guillaume Vaiva; Etienne Véry; Axel Bourcier; Antoine Yrondi; Laetitia Dupuch; Pierre Lamy; Claire Thalamas; Laurence Jasse; Wissam El Hage; Philippe Birmes is a Neuroscience article available to read on EtoBox.
What is Traumatic memory reactivation with or without propranolol for PTSD and comorbid MD symptoms: a randomised clinical trial about?
Post-traumatic stress disorder (PTSD) is difficult to treat but one promising strategy is to block memory reconsolidation of the traumatic event. This study aimed to evaluate the efficacy of traumatic memory reactivation under the influence of propranolol, a noradrenergic beta-receptor blocker, in reducing PTSD symptoms as well as comorbid major depression (MD) symptoms. We conducted a double blind, placebo-controlled, randomised clinical trial in 66 adults diagnosed with longstanding PTSD. Propranolol or a placebo was administered 90 min before a brief memory reactivation session, once a week for 6 consecutive weeks. Measures included the SCID PTSD module, the PTSD Check List (PCL-S) and the Beck Depression Inventory-II (BDI-II). PTSD symptoms decreased both in the pre-reactivation propranolol group (39.28%) and the pre-reactivation placebo group (34.48 %). During the 6 treatment sessions, PCL-S and BDI-II scores decreased to similar extent in both groups and there were no treatment differences. During the 3-month follow-up period, there were no treatment effects for the mean PCL-S and BDI-II scores. However, in patients with severe PTSD symptoms (PCL-S ≥ 65) before treatment, PCL
Who reads Traumatic memory reactivation with or without propranolol for PTSD and comorbid MD symptoms: a randomised clinical trial?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Pascal Roullet; Guillaume Vaiva; Etienne Véry; Axel Bourcier; Antoine Yrondi; Laetitia Dupuch; Pierre Lamy; Claire Thalamas; Laurence Jasse; Wissam El Hage; Philippe Birmes
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Neuroscience (Life Sciences)