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The reduction of DSS-induced colitis severity in mice exposed to cigarette smoke is linked to immune modulation and microbial shifts by Lo Sasso, Giuseppe; Phillips, Blaine W.; Sewer, Alain; Battey, James N. D.; Kondylis, Athanasios; Talikka, Marja; Titz, Bjoern; Guedj, Emmanuel; Peric, Dariusz; Bornand, David; Dulize, Remi; Merg, Celine; Corciulo, Maica; Ouadi, Sonia; Yanuar, Rendy; Tung, Ching Keong; Ivanov, Nikolai V.; Peitsch, Manuel C.; Hoeng, Julia is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Exposure to cigarette smoke (CS) causes detrimental health effects, increasing the risk of cardiovascular, pulmonary diseases and carcinogenesis in exposed individuals. The impact of CS on Inflammatory Bowel Disease (IBD) has been established by a number of epidemiological and clinical studies. In fact, CS is associated with a higher risk of developing Crohn’s disease (CD) while inversely correlates with the development, disease risks, and relapse rate of ulcerative colitis (UC). To investigate the effect of CS exposure on experimental colitis, we performed a comprehensive and integrated comparative analysis of colon transcriptome and microbiome in mice exposed to dextran sodium sulfate (DSS) and CS. Colon transcriptome analysis revealed that CS downregulated specific pathways in a concentration-dependent manner, affecting both the inflammatory state and composition of the gut microbiome. Metagenomics analysis demonstrated that CS can modulate DSS-induced dysbiosis of specific bacterial genera, contributing to resolve the inflammation or accelerate recovery. The risks of smoking far outweigh any possible benefit, thus smoking cessation must always be encouraged because of its signi

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Author

Lo Sasso, Giuseppe; Phillips, Blaine W.; Sewer, Alain; Battey, James N. D.; Kondylis, Athanasios; Talikka, Marja; Titz, Bjoern; Guedj, Emmanuel; Peric, Dariusz; Bornand, David; Dulize, Remi; Merg, Celine; Corciulo, Maica; Ouadi, Sonia; Yanuar, Rendy; Tung, Ching Keong; Ivanov, Nikolai V.; Peitsch, Manuel C.; Hoeng, Julia

Publisher

Springer Science and Business Media LLC; London: Nature Publishing Group; [London]: Springer Nature; Nature Publishing Group; Society for Mining, Metallurgy and Exploration Inc.; Research Square; Springer Nature; Island Press (ISSN 2045-2322)

Published

2020

Language

EN

ISBN

9784159802067

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)