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Can I read An All-in-one Theranostic Nanoplatform Based on Upconversion Dendritic Mesoporous Silica Nanocomposites for Synergistic Chemodynamic/photodynamic/gas Therapy on EtoBox?
An All-in-one Theranostic Nanoplatform Based on Upconversion Dendritic Mesoporous Silica Nanocomposites for Synergistic Chemodynamic/photodynamic/gas Therapy by Shikai Liu; Wenting Li; Shuming Dong; Fangmei Zhang; Yushan Dong; Boshi Tian; Fei He; Shili Gai; Piaoping Yang is a Materials Science article available to read on EtoBox.
What is An All-in-one Theranostic Nanoplatform Based on Upconversion Dendritic Mesoporous Silica Nanocomposites for Synergistic Chemodynamic/photodynamic/gas Therapy about?
Gasotransmitters with high therapeutic efficacy and biosafety have been drawing the attention of researchers. Nevertheless, how to effectively deliver gases to and precisely control their generation at the lesion as well as integrate them with other therapies to realize precision therapy have remained elusive. Herein, we report a versatile Cu-initiated nitric oxide (NO) nanocomposite for multimodal imaging-guided synergistic chemodynamic/photodynamic/gas therapy. After the nanomedicine was ingested by tumor cells, the acidic tumor microenvironment accelerated the decomposition of CuO and simultaneously triggered the Fenton-like catalytic reaction of Cu and HO to produce highly toxic ̇OH. By virtue of the NO generation and glutathione depletion, UMNOCC-PEG can relieve the antioxidant capacity and hypoxia of the tumor to improve the efficiency of chemodynamic therapy (CDT) and photodynamic therapy (PDT). Importantly, NO and reactive oxygen species (ROS) can generate reactive nitrogen species (RNS), which can result in DNA damage, further improving the therapeutic effect (cell apoptosis rate up to 93.4%). Moreover, the inherent properties of lanthanide ions endow UMNOCC-PEG with upco
Who reads An All-in-one Theranostic Nanoplatform Based on Upconversion Dendritic Mesoporous Silica Nanocomposites for Synergistic Chemodynamic/photodynamic/gas Therapy?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Shikai Liu; Wenting Li; Shuming Dong; Fangmei Zhang; Yushan Dong; Boshi Tian; Fei He; Shili Gai; Piaoping Yang
- Published
- 2020
- Language
- EN
- Field
- Materials Science (Physical Sciences)