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The study by Luchetti et al. identifies the Shigella ubiquitin ligase IpaH7.8 as a specific inhibitor of pyroptosis in human cells by targeting the protein gasdermin D (GSDMD) for degradation. This mechanism allows Shigella to evade host immune responses and contribute to severe gastroenteritis in humans, while not affecting mice. The findings highlight the evolutionary arms race between pathogens and host defenses, emphasizing the species-specific nature of Shigella

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roloh12099

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