Can I read Early Up-regulation of Chemokine Expression in Fulminant Hepatic Failure on EtoBox?

Early Up-regulation of Chemokine Expression in Fulminant Hepatic Failure by Ludger Leifeld; Franz-Ludwig Dumoulin; Ingvill Purr; Katrin Janberg; Christian Trautwein; Martin Wolff; Michael Peter Manns; Tilman Sauerbruch; Ulrich Spengler is a Medicine article available to read on EtoBox.

What is Early Up-regulation of Chemokine Expression in Fulminant Hepatic Failure about?

## Abstract CC‐chemokines recruit and activate macrophages and T lymphocytes, the major components of inflammatory infiltrates in fulminant hepatic failure (FHF). To analyse the role of CC‐chemokines in the pathogenesis of FHF, this study examined serum levels and intrahepatic expression of MCP‐1, MIP‐1α, MIP‐1β, and RANTES in the livers and sera of patients with FHF and controls by ELISA, immunohistochemistry, and competitive RT‐PCR. Serum levels and intrahepatic expression of all chemokines studied in FHF exceeded the levels in chronic liver diseases and normal controls. Distinct patterns of expression of each chemokine were noted on Kupffer cells, sinusoidal endothelial cells, hepatocytes, lymphocytes, and bile ducts. Intrahepatic chemokine expression correlated closely with the extent of infiltration by macrophages and T lymphocytes (__r__ = 0.65–0.95, __p__ < 0.001). The functional relationship between intrahepatic chemokine release and infiltration was confirmed in chemotaxis assays by inhibiting chemotaxis induced by homogenates of liver tissue obtained from FHF patients with neutralizing MCP‐1, MIP‐1α, MIP‐1β, and RANTES antibodies. The time course of CC‐chemokine release w

Who reads Early Up-regulation of Chemokine Expression in Fulminant Hepatic Failure?

Author

Ludger Leifeld; Franz-Ludwig Dumoulin; Ingvill Purr; Katrin Janberg; Christian Trautwein; Martin Wolff; Michael Peter Manns; Tilman Sauerbruch; Ulrich Spengler

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

2003

Language

EN

Field

Medicine (Health Sciences)