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Analysis of T-cell immune response in renal cell carcinoma: Polarization to type 1-like differentiation pattern, clonal T-cell expansion and tumor-specific cytotoxicity by Eric Angevin; Florence Kremer; Catherine Gaudin; Thierry Hercend; Frédéric Triebel is a Medicine article available to read on EtoBox.
What is Analysis of T-cell immune response in renal cell carcinoma: Polarization to type 1-like differentiation pattern, clonal T-cell expansion and tumor-specific cytotoxicity about?
We assessed the naturally occurring T-cell immune response in primary renal cell carcinoma (RCC) tumors from 12 unselected patients. A predominance of CD3 1 T-cell receptor (TCR)a/b 1 T cells was observed in tumor-infiltrating lymphocytes (TILs), in contrast with peripheral blood lymphopenia found in some patients. Activation antigen expression on TILs revealed an imbalance in the activation status, with a significant percentage of CD69 1 and HLA-DR 1 and a low percentage of CD25 1 and CD71 1 TILs. The lymphocyte activation gene-3 (LAG-3) was detected in some TIL subpopulations and especially in one patient in whom TILs were predominantly TCRa/b 1 CD8 1 DR 1 LAG-3 1 . In addition, we found that RCC TILs are polarized to a global type 1-like (Th1/Tc1) differentiation pattern (strong secretion of interferon-g and interleukin-2 (IL-2) following CD3/TCR crosslinking) but are under the influence of the down-modulatory cytokines IL-6 (secreted by tumor cells) and IL-10, within the tumor microenvironment. In 3 of 5 patients, clonal T-cell expansion at the tumor site was found for several Vb specificities, suggesting that in situ stimulation of specific clonotypes in response to potential
Who reads Analysis of T-cell immune response in renal cell carcinoma: Polarization to type 1-like differentiation pattern, clonal T-cell expansion and tumor-specific cytotoxicity?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Eric Angevin; Florence Kremer; Catherine Gaudin; Thierry Hercend; Frédéric Triebel
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1997
- Language
- EN
- Field
- Medicine (Health Sciences)