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Can I read Population Pharmacokinetics of Methadone in Opiate Users: Characterization of Time-dependent Changes on EtoBox?
Population Pharmacokinetics of Methadone in Opiate Users: Characterization of Time-dependent Changes by Amin Rostami-Hodjegan; Kim Wolff; Alastair W. M. Hay; Duncan Raistrick; Robert Calvert; Geoffrey T. Tucker is a Medicine article available to read on EtoBox.
What is Population Pharmacokinetics of Methadone in Opiate Users: Characterization of Time-dependent Changes about?
__Aims__ Although methadone is widely used to treat opiate dependence, guidelines for its dosage are poorly defined. There is increasing evidence to suggest that a strategy based on plasma drug monitoring may be useful to detect non‐compliance. Therefore, we have developed a population‐based pharmacokinetic (POP‐PK) model that characterises adaptive changes in methadone kinetics. __Methods Sparse plasma rac‐methadone concentrations measured in 35 opiate‐users were assessed using the P‐Pharm software. The final structural model comprised a biexponential function with first‐order input and allowance for time‐dependent change in both clearance (CL) and initial volume of distribution (V__ ). Values of these parameters were allowed to increase or decrease exponentially to an asymptotic value. __Results Increase in individual values of CL and increase or decrease in individual values of V__ with time was observed in applying the model to the experimental data. __Conclusions A time‐dependent increase in the clearance of methadone is consistent with auto‐induction of CYP3A4, the enzyme responsible for much of the metabolism of the drug. The changes in V with time might reflect both up‐ an
Who reads Population Pharmacokinetics of Methadone in Opiate Users: Characterization of Time-dependent Changes?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Amin Rostami-Hodjegan; Kim Wolff; Alastair W. M. Hay; Duncan Raistrick; Robert Calvert; Geoffrey T. Tucker
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0306-5251)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)