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Can I read Liposomal daunorubicin (DaunoXome) plus dexamethasone for patients with multiple myeloma : A Phase II International Oncology Study Group study on EtoBox?
Liposomal daunorubicin (DaunoXome) plus dexamethasone for patients with multiple myeloma : A Phase II International Oncology Study Group study by Ann F. Mohrbacher; Stephanie A. Gregory; Don A. Gabriel; Jason M. Rusk; Francis J. Giles is a Medicine article available to read on EtoBox.
What is Liposomal daunorubicin (DaunoXome) plus dexamethasone for patients with multiple myeloma : A Phase II International Oncology Study Group study about?
## Abstract ## BACKGROUND Liposomal daunorubicin is an effective cytotoxic agent in patients with Kaposi sarcoma and hematologic malignancies. Anthracycline‐based chemotherapy regimens, such as vincristine/doxorubicin/dexamethasone (VAD), are standard in the treatment of patients with multiple myeloma (MM). Cardiotoxicity remains a limiting factor in dose escalation of anthracyclines, and multidrug resistance (MDR) develops rapidly on exposure to anthracyclines. Liposomal daunorubicin was designed in an attempt to overcome MDR and to reduce anthracycline‐related toxicities. Thus, an open‐label, Phase II clinical study was conducted by the International Oncology Study Group to assess the efficacy and safety of intravenous liposomal daunorubicin at a dose of 100 mg/m^2^ given every 3 weeks for a maximum of 6 cycles in patients with recently diagnosed MM (__n__ = 4 patients) or recurrent/refractory MM (__n__ = 37 patients). ## METHODS Liposomal daunorubicin was administered as a single agent for the initial two cycles of therapy, and dexamethasone was added to all subsequent cycles. The primary study end point was response rates. Thirty‐eight patients were treated, 35 of whom were eva
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- Author
- Ann F. Mohrbacher; Stephanie A. Gregory; Don A. Gabriel; Jason M. Rusk; Francis J. Giles
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)