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This document summarizes a study that aimed to improve the entrapment efficiency of a hydrophilic drug, sodium cromoglycate, inside polylactic acid nanoparticles using a modified nanoprecipitation method. The researchers tested different formulation parameters including solvent selection, drug amount, pH alteration, and electrolyte addition and found that lowering the pH during nanoparticle formation was the most effective way to increase drug loading from 10-15% to approximately 70%. X-ray diffraction anal

Author

smitthhaa

Language

EN