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Mif: A Most Interesting Factor by Richard Bucala, Richard Bucala is a nonfiction available to read on EtoBox.

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Although first described as a soluble activity produced by activated T cells nearly four decades ago, interest in macrophage migration inhibitory factor (MIF) was rekindled when the mouse homolog of this protein was identified to be secreted from the anterior pituitary gland in a hormone-like fashion (Bernhagen et aL, 1993). Initially. MIF was shown to play a critical role in the host inflammatory response to endotoxin. Further studies showed that the inflammatory activity of MIF was mediated by its ability to promote proinflammatory cytokine release (Calandra et aL. 1994) and to suppress the anti-inflammatory effects of glucocorticoids (Calandra et aL. 1995; Bacher et aL. 1996). Since the identification of MIF as a unique proinflammatory molecule and the development of neutralizing monoclonal antibodies, several reports have been published describing the role of MIF in inflammatory diseases, including arthritis, glomerulonephritis, peritonitis, and the delayed-type hypersensitivity reaction. Clinical evidence demonstrating increased MIF expression during inflammatory disease pathogenesis further supports the potential role of MIF in inflammation. In addition to its role in the inf

Who reads Mif: A Most Interesting Factor?

Author

Richard Bucala, Richard Bucala

Publisher

World Scientific Publishing Company

Published

2007

Language

EN

ISBN

9789812775917

Category

nonfiction

Subjects

Medical, Science, Biology