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What is Robinson Annulation of Ethyl Acetoacetate about?
The experiment performs a Robinson annulation reaction to synthesize an α,β-unsaturated cyclic ketone. Trans-chalcone and ethyl acetoacetate are reacted using sodium hydroxide catalyst to undergo Michael addition followed by aldol condensation. This yields the product 6-ethoxycarbonyl-3,5-diphenyl-2-cyclohexenone. The percent yield is calculated to be 8.06% based on characterization including NMR spectroscopy and melting point determination.
- Author
- Muhammad Amirul Afifi
- Language
- EN