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This document reports on a study that investigated selectively eliminating immunodominant B cells during an active germinal center (GC) immune response. The researchers found that treating with soluble antigen containing only the dominant epitope could suppress immunodominant GC B cells. This allowed subdominant B cells to expand without competition and generate an improved long-lived humoral immune response against subdominant epitopes.

Author

Zadorxs

Language

EN