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Racial/ethnic variation in EBV-positive classical Hodgkin lymphoma in California populations by Sally L. Glaser; Margaret L. Gulley; Christina A. Clarke; Theresa H. Keegan; Ellen T. Chang; Sarah J. Shema; Fiona E. Craig; Joseph A. DiGiuseppe; Ronald F. Dorfman; Risa B. Mann; Hoda Anton‐Culver; Richard F. Ambinder is a Medicine article available to read on EtoBox.
What is Racial/ethnic variation in EBV-positive classical Hodgkin lymphoma in California populations about?
## Abstract Epstein‐Barr virus (EBV) is detected in the tumor cells of some but not all Hodgkin lymphoma (HL) patients, and evidence indicates that EBV‐positive and ‐negative HL are distinct entities. Racial/ethnic variation in EBV‐positive HL in international comparisons suggests etiologic roles for environmental and genetic factors, but these studies used clinical series and evaluated EBV presence by differing protocols. Therefore, we evaluated EBV presence in the tumors of a large (__n__ = 1,032), racially and sociodemographically diverse series of California incident classical HL cases with uniform pathology re‐review and EBV detection methods. Tumor EBV‐positivity was associated with Hispanic and Asian/Pacific Islander (API) but not black race/ethnicity, irrespective of demographic and clinical factors. Complex race‐specific associations were observed between EBV‐positive HL and age, sex, histology, stage, neighborhood socioeconomic status (SES), and birth place. In Hispanics, EBV‐positive HL was associated not only with young and older age, male sex, and mixed cellularity histology, but also with foreign birth and lower SES in females, suggesting immune function responses to
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- Author
- Sally L. Glaser; Margaret L. Gulley; Christina A. Clarke; Theresa H. Keegan; Ellen T. Chang; Sarah J. Shema; Fiona E. Craig; Joseph A. DiGiuseppe; Ronald F. Dorfman; Risa B. Mann; Hoda Anton‐Culver; Richard F. Ambinder
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)