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Evidence for alternative lengthening of telomeres in liposarcomas in the absence of ALT‐associated PML bodies by Jennie N. Jeyapalan; Aaron Mendez‐Bermudez; Nadia Zaffaroni; Yuri E. Dubrova; Nicola J. Royle is a Medicine article available to read on EtoBox.
What is Evidence for alternative lengthening of telomeres in liposarcomas in the absence of ALT‐associated PML bodies about?
## Abstract Immortalized and cancer cells maintain their telomeres by activation of a telomere maintenance mechanism (TMM). In ∼85% of cancers telomerase is activated (TA) but in some tumours, in particular sarcomas, an alternative lengthening of telomeres (ALT) pathway is used. Liposarcomas are the most common soft‐tissue sarcoma in adults and they activate ALT or telomerase with equal frequency, however no TMM has been identified in ∼50% of liposarcomas. In our study, we have shown that instability at the minisatellite MS32, usually associated with ALT activation, aids the identification of liposarcomas that have recombination‐like activity at telomeres in absence of ALT associated PML‐bodies (APBs). Furthermore, using single molecule telomere analysis, we have detected complex telomere mutations directly in ALT positive liposarcomas and interestingly in some liposarcomas with an unknown TMM but high MS32 instability. We have shown by sequence analysis that some of these complex telomere mutations must arise by an inter‐molecular recombination‐like process rather than by deletion caused by __t__‐loop excision or by unequal telomere‐sister‐chromatid‐exchange (T‐SCE), which is know
Who reads Evidence for alternative lengthening of telomeres in liposarcomas in the absence of ALT‐associated PML bodies?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Jennie N. Jeyapalan; Aaron Mendez‐Bermudez; Nadia Zaffaroni; Yuri E. Dubrova; Nicola J. Royle
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)