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Can I read Microglial Lineage Species Are Expressed in Mammalian Epidermal Growth Factor-generated Embryonic Neurospheres on EtoBox?
Microglial Lineage Species Are Expressed in Mammalian Epidermal Growth Factor-generated Embryonic Neurospheres by Achilles K. Papavasiliou; Mark F. Mehler; Kostantin Dobrenis; Ronen Marmur; Peter C. Mabie; John A. Kessler is a Neuroscience article available to read on EtoBox.
What is Microglial Lineage Species Are Expressed in Mammalian Epidermal Growth Factor-generated Embryonic Neurospheres about?
The epigenetic signals and progenitor cell species involved in progressive neural maturation in the mammalian brain are poorly understood. Although these complex developmental issues can be examined in cultures of generative zone progenitor cells, analysis of signaling relationships in complex progenitor cell systems requires the meticulous definition of the cellular complement at each developmental stage. The presence of microglia within the generative zone cultures would further complicate these developmental analyses. Utilizing the microglial markers Griffo- nia simplicifolia B, isolectin, carbocyanine dye-acetylated low density lipoprotein, F4l80, and Mac-1 we now report the presence of microglia within cultures of late embryonic murine epidermal growth factorderived generative zone progenitor cells. Cytokine treatment of serially passaged epidermal growth factor-generated neurospheres altered the phenotype of the microglia in culture. Macrophage colonystimulating factor treatment promoted the expression of spindle-shaped microglia, whereas granulocytemacrophage colony-stimulating factor treatment promoted the elaboration of flat and amoeboid microglia. Treatment with microglia
Who reads Microglial Lineage Species Are Expressed in Mammalian Epidermal Growth Factor-generated Embryonic Neurospheres?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Achilles K. Papavasiliou; Mark F. Mehler; Kostantin Dobrenis; Ronen Marmur; Peter C. Mabie; John A. Kessler
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 1996
- Language
- EN
- Field
- Neuroscience (Life Sciences)