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Prematurity Attenuates Skeletal Muscle Anabolism of Neonatal Pigs Independently of Birth Weight by Marko Rudar; Jane Naberhuis; Agus Suryawan; Hanh Nguyen; Marta Fiorotto; Teresa Davis is a Medicine article available to read on EtoBox.

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## Abstract ## Objectives Premature infants are at risk for postnatal growth failure that reduces lifelong lean mass. We have shown previously that preterm birth blunts the feeding-induced activation of the mechanistic target of rapamycin (mTOR) signaling pathway, translation initiation, and protein synthesis in skeletal muscle of neonatal pigs. Considering that body weight can vary widely at birth, we sought to separate the effect of prematurity from birth weight on the anabolic response to feeding. ## Methods Pigs were delivered by cesarean section at preterm (103 d) or term (112 d) gestation and fed parenterally for 4 d. On day 4, pigs were fasted for 4 h and were either fasted one additional hour or fed by oral gavage, yielding four groups: 1) preterm fasted (PT-FAST); 2) preterm fed (PT-FED); 3) term fasted (T-FAST); and 4) term fed (T-FED). All pigs were injected with a flooding dose of L-[4-^3^H]Phe to determine fractional protein synthesis rates and euthanized 60 min after feeding or the additional fast. Pigs were stratified by birth weight such that the highest birth weight preterm pigs were compared with the lowest birth weight term pigs (n = 10–13 per group). ## Results

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Author

Marko Rudar; Jane Naberhuis; Agus Suryawan; Hanh Nguyen; Marta Fiorotto; Teresa Davis

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)