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Can I read New progesterone receptor antagonists: Phosphorus-containing 11β-aryl-substituted steroids on EtoBox?
New progesterone receptor antagonists: Phosphorus-containing 11β-aryl-substituted steroids by Weiqin Jiang; George Allan; James J. Fiordeliso; Olivia Linton; Pamela Tannenbaum; Jun Xu; Peifang Zhu; Joseph Gunnet; Keith Demarest; Scott Lundeen; Zhihua Sui is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is New progesterone receptor antagonists: Phosphorus-containing 11β-aryl-substituted steroids about?
A new series of phosphorus-containing 11b-aryl-substituted steroids have been synthesized in an eight-step sequence involving a palladium-catalyzed coupling reaction to introduce a phosphorus group onto the aromatic ring. The compounds were evaluated for progesterone receptor (PR) antagonist activity in a T47D cell-based assay and for glucocorticoid receptor (GR) antagonist activity in an A549 cell-based assay. The structure-activity relationships of these compounds are discussed. Selected compounds were tested in vivo in a rat complement C3 assay.
Who reads New progesterone receptor antagonists: Phosphorus-containing 11β-aryl-substituted steroids?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Weiqin Jiang; George Allan; James J. Fiordeliso; Olivia Linton; Pamela Tannenbaum; Jun Xu; Peifang Zhu; Joseph Gunnet; Keith Demarest; Scott Lundeen; Zhihua Sui
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)
- Published
- 2006
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)