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Can I read Molecular Insights into Dynein Autoinhibition on EtoBox?
Molecular Insights into Dynein Autoinhibition by Marzo, Matthew G. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Molecular Insights into Dynein Autoinhibition about?
We investigated contraction-relaxation coupling using a computer model (My-oSim) that simulates dynamically coupled thick and thin filaments and includes force-dependent transitions between the OFF and ON states of myosin. Initial calculations simulated twitch contractions at different muscle lengths and exhibited contraction-relaxation coupling. We then perturbed the model by systematically varying the values of parameters associated with each sarcomere-level process. This produced a wide range of twitch responses. Contraction-relaxation coupling was maintained in nearly every case. The only exceptions were observed due to the perturbations which reduced the occupancy of the myosin OFF state. We conclude that rapid transitions from the ON to the OFF state of myosin are essential for contraction-relaxation coupling.
Who reads Molecular Insights into Dynein Autoinhibition?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Marzo, Matthew G.
- Publisher
- Biophysical Society; Elsevier ; Elsevier BV (ISSN 0006-3495)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)