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Collision-induced fragmentation of negative ions from N-linked glycans derivatized with 2-aminobenzoic acid by David J. Harvey is a Chemistry article available to read on EtoBox.

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## Abstract __N__‐Linked glycans from bovine ribonuclease B, chicken ovalbumin, bovine fetuin, porcine thyroglobulin and human α~1~‐acid glycoprotein were derivatized with 2‐aminobenzoic acid by reductive amination and their tandem mass spectra were recorded by negative ion electrospray ionization with a quadrupole time‐of‐flight mass spectrometer. Derivatives were also prepared from 2‐amino‐5‐methyl‐ and 2‐amino‐4,5‐dimethoxybenzoic acid in order to confirm the identity of fragment ions containing the reducing terminus. Major fragments from the [M − H]^−^ ions from the neutral glycans retained the derivative (Y‐type cleavages) and provided information on sequence and branching. Other major fragments were products of A‐type cross‐ring cleavages giving information on antenna structure. Singly doubly and triply charged ions were formed from sialylated glycans. They produced major fragments by loss of sialic acid and a series of singly charged ions that were similar to those from the neutral analogues. Doubly charge ions were also produced by the neutral glycans and were fragmented to form product ions with one and two charges. Again, the fragment ions with a single charge were simila

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Author

David J. Harvey

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley-Liss Inc; John Wiley & Sons Inc.; Wiley; Heyden And Son (ISSN 1076-5174)

Published

2005

Language

EN

Field

Chemistry (Physical Sciences)