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Interactions Between Genetic Predisposition and Environmental Toxicants for Development of Lung Cancer by Randa El-Zein; Nivea Conforti-Froes; William W. Au is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Significant interindividual variations in health outcome may be caused by the inheritance of variant polymorphic genes, such as CYP2D6 and CYP2E1 for activation, and GSTM1 and GSTT1 for detoxification of chemicals. However, mechanistic studies linking the inheritance of predisposing genes with genotoxic effects towards cancer have yet to be systematically conducted. We have studied 54 lung cancer patients and 50 matched normal controls, who have been cigarette smokers, to elucidate the role of polymorphic genes in cancer. Our data indicates that the inheritance of unfavorable CYP2D6, CYP2E1, and GSTT1 genes in strongly correlated with the smoking-related lung cancer. For heavy cigarette smokers (> 30 pack-years), the smoking habit is the strongest predictor of lung cancer risk irrespective of the inheritance of unfavorable metabolizing genes. For moderate to light smokers (< 30 pack-years), the genetic predisposition plays an important role for the risk (odds ratio = 3.46; 95% Cl = 0.46-40.2). Using a subgroup of the study population, we observed that cigarette smokers having the defective GST genes have significantly more chromosome aberrations as determined by the fluorescence-in

Who reads Interactions Between Genetic Predisposition and Environmental Toxicants for Development of Lung Cancer?

Author

Randa El-Zein; Nivea Conforti-Froes; William W. Au

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0893-6692)

Published

1996

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)