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Monoclonal Antibodies in Treating High Cholesterol Levels by Rostislav Večeřa is a scholarly article available to read on EtoBox.

What is Monoclonal Antibodies in Treating High Cholesterol Levels about?

Proprotein convertase subtilisin-kexin type 9 (PCSK9) is mainly responsible for the recycling receptors for LDL particles. This results in an increasein LDL levels, which then drastically contributes to the development of atherosclerotic changes in vessel wall. This increases cardiovascularmorbidity and mortality. New drugs based on monoclonal antibodies as alirocumab or evolocumab belongs among PCSK9 inhibitors. Theiradministration leads to a dramatic reduction in LDL particles up to 50–60 %. Given that the Czech Republic ranks among the countries withhigh cardiovascular mortality, is introduction of these new drugs in clinical practice one of the key milestones in the treatment of high bloodlipid levels and improve this negative situation.

Author

Rostislav Večeřa

Publisher

Praktické lékárenství

Published

2018