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This study evaluated the effects of an orally administered mixture of chondroitin sulfate, glucosamine hydrochloride, and manganese ascorbate on articular cartilage metabolism in dogs with cranial cruciate ligament deficiency. Results showed that treated dogs had significantly elevated concentrations of synovial fluid 3B3 and 7D4 epitopes compared to controls, indicating potential modulation of cartilage matrix metabolism. However, the treatment effect was not significant when expressed as a ratio of operat

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lbmds

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