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Can I read The Regiocontrollable Enantioselective Synthesis of Chiral Trifluoromethyl-Containing Spiro-Pyrrolidine-Pyrazolone Compounds via Amino-Regulated 1,3-Proton Migration Reaction on EtoBox?
The Regiocontrollable Enantioselective Synthesis of Chiral Trifluoromethyl-Containing Spiro-Pyrrolidine-Pyrazolone Compounds via Amino-Regulated 1,3-Proton Migration Reaction by Yabo Deng; Zhenghao Dong; Fengyun Gao; Yifei Guo; Mengmeng Sun; Yongzhen Li; Yalan Wang; Qushuo Chen; Kairong Wang; Wenjin Yan is a Chemistry article available to read on EtoBox.
What is The Regiocontrollable Enantioselective Synthesis of Chiral Trifluoromethyl-Containing Spiro-Pyrrolidine-Pyrazolone Compounds via Amino-Regulated 1,3-Proton Migration Reaction about?
An amino-controlled regiodivergent asymmetric synthesis of CF-containing spiro-pyrrolidine-pyrazolone compounds is described. With alkaloid-derived squaramide as catalyst, the 1,3-dipolar cycloaddition of α,β-unsaturated pyrazolone with diethyl 2-((2,2,2-trifluoroethyl)imino) malonate offered adducts in excellent yields, dr, and ee. While the cyclohexanediamine-derived squaramide was employed, the reaction afforded a series of structure isomers through a switched umpolung reaction.
Who reads The Regiocontrollable Enantioselective Synthesis of Chiral Trifluoromethyl-Containing Spiro-Pyrrolidine-Pyrazolone Compounds via Amino-Regulated 1,3-Proton Migration Reaction?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Yabo Deng; Zhenghao Dong; Fengyun Gao; Yifei Guo; Mengmeng Sun; Yongzhen Li; Yalan Wang; Qushuo Chen; Kairong Wang; Wenjin Yan
- Publisher
- American Chemical Society (ACS)
- Published
- 2021
- Language
- EN
- Field
- Chemistry (Physical Sciences)