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Quantifying Methane and Methanol Metabolism of “ Methylotuvimicrobium buryatense ” 5GB1C under Substrate Limitation by He, Lian; Fu, Yanfen; Lidstrom, Mary E.; Mackelprang, Rachel is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Quantifying Methane and Methanol Metabolism of “ Methylotuvimicrobium buryatense ” 5GB1C under Substrate Limitation about?

Methanotrophic metabolism has been under investigation for decades using biochemical and genetic approaches. Recently, a further step has been taken toward understanding methanotrophic metabolism in a quantitative manner by means of flux balance analysis (FBA), a mathematical approach that predicts fluxes constrained by mass balance and a few experimental measurements. However, no study has previously been undertaken to experimentally quantitate the complete methanotrophic central metabolism. The significance of this study is to fill such a gap by performing 13 C INST-MFA on a fast-growing methanotroph. Our quantitative insights into the methanotrophic carbon and energy metabolism will pave the way for future FBA studies and set the stage for rational design of methanotrophic strains for industrial applications. Further, the experimental strategies can be applied to other methane or methanol utilizers, and the results will offer a unique and quantitative perspective of diverse methylotrophic metabolism.

Who reads Quantifying Methane and Methanol Metabolism of “ Methylotuvimicrobium buryatense ” 5GB1C under Substrate Limitation?

Author

He, Lian; Fu, Yanfen; Lidstrom, Mary E.; Mackelprang, Rachel

Publisher

American Society for Microbiology; Washington DC: American Society for Microbiology, [2016]- (ISSN 2379-5077)

Published

2019

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)